目的 研究酸藤果的化学成分。方法 利用MCI、中压硅胶柱色谱、反相硅胶柱色谱及半制备高效液相色谱等方法对酸藤果醇提取物进行分离纯化，依据所得化合物的理化性质与波谱数据鉴定其结构。结果 分离纯化并鉴定了15个化合物，分别为nantenine(1)、oxonantenine(2)、大黄素甲醚(3)、丁香酸(4)、香草酸(5)、stigmast-4-ene-3，6-dione(6)、(+)-lyoniresinol(7)、7S，8S-threo-4，7，9，9′-tetrahydroxy-3，3′-dimethoxy-8-O-4′-neolignan(8)、1，3-dihydroxylprop-yl-(9Z，12Z)-octadeca-9，12-dienate(9)、(22E)-5a，8a-epidioxyergosta-6，22-dien-3b-ol(10)、dihydroxyisoechinulin A(11)、对羟基苯甲酸(12)、豆甾醇(13)、谷甾醇(14)和胡萝卜苷(15)。结论 化合物1、2和5~13为首次从该属植物中分离得到，化合物1~15为首次从该植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of the fruits of Embelia laeta. METHODS The compounds were isolated and purified by MCI,medium pressure TLC on silica gel column, ODS column chromatography, semi-preparative HPLC, and so on. The structures were elucidated on the basis of various modern spectroscopic techniques using physical, chemical properties and spectral data. RESULTS Fifteen compounds were isolated and identified as nantenine(1), oxonantenine(2), physcion(3), syringic acid(4), vanillic acid(5), stigmast-4-ene-3,6-dione(6),(+)-lyoniresinol(7), 7S,8S-threo-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolignan(8), 1,3-dihydroxylpropyl-(9Z,12Z)-octadeca-9,12-dienate(9),(22E)-5a,8a-epidioxyergosta-6,22-dien-3b-ol(10), dihydroxyisoechinulin A(11), hydroxybenzoic acid(12), stigmasterol(13), sitosterol(14), and daucosterol(15). CONCLUSION Compounds 1, 2, and 5-13 are isolated from the genus Embelia for the first time, and compounds 1-15 are isolated from this plant for the first time.
关键词
酸藤果 /
nantenine /
oxonantenine /
大黄素甲醚 /
丁香酸
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Key words
Embelia laeta /
nantenine /
oxonantenine /
physcion /
syringic acid
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中图分类号：
R284
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参考文献
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脚注
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基金
江西民族传统药现代科技与产业发展协同创新中心开放基金资助项目(JXXT201402013)
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